Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis.

ABSTRACT: Translational efforts in osteoarthritis are hampered by a gap in our understanding of disease processes at the molecular level. Here, we present evidence of pronounced transcriptional changes in high- and low-disease-grade cartilage tissue, pointing to embryonic processes involved in disease progression. We identify shared transcriptional programs between osteoarthritis cartilage and cell populations in the human embryonic and fetal limb, pointing to increases in pre-hypertrophic chondrocytes' transcriptional programs in low-grade cartilage and increases in osteoblastic signatures in high-grade disease tissue. We find that osteoarthritis genetic risk signals are enriched in six gene co-expression modules and show that these transcriptional signatures reflect cell-type-specific expression a

SUBMITTER: Katsoula G 

PROVIDER: S-EPMC11639091 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature