The PRIMED Consortium: Reducing disparities in polygenic risk assessment.

ABSTRACT: By improving disease risk prediction, polygenic risk scores (PRSs) could have a significant impact on health promotion and disease prevention. Due to the historical oversampling of populations with European ancestry for genome-wide association studies, PRSs perform less well in other, understudied populations, leading to concerns that clinical use in their current forms could widen health care disparities. The PRIMED Consortium was established to develop methods to improve the performance of PRSs in global populations and individuals of diverse genetic ancestry. To this end, PRIMED is aggregating and harmonizing multiple phenotype and genotype datasets on AnVIL, an interoperable secure cloud-based platform, to perform individual- and summary-level analyses using population and statistical

SUBMITTER: Kullo IJ 

PROVIDER: S-EPMC11639095 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature