Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study.

ABSTRACT:

Objective

The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies. Here we investigated effects of CAR-T cells on the innate immune system which is an important contributor to pathology in SSc.

Methods

Longitudinal analysis of peripheral blood mononuclear cells from an Scl70 + SSc patient treated with CAR-T cells sampled over 18 months by 29-color spectral flow cytometry, in vitro experiments using sera from patient cohorts.

Results

In the patient treated with CAR-T cells, the substantial clinical improvement was paralleled by dynamic changes in innate lymphoid cells, namely Fcγ-receptor IIIA-expressing natural killer (NK) cells. NK cells adopted a more juvenile, less

SUBMITTER: Claus M 

PROVIDER: S-EPMC11639114 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature