REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial.

ABSTRACT:

Background

Cardiopulmonary bypass (CPB) triggers marked cytokine release often followed by a systemic inflammatory response syndrome, associated with adverse postoperative outcomes. This trial investigates the intraoperative use of haemoadsorption (HA) during cardiac surgery with CPB to assess its impact on postoperative systemic inflammatory response.

Methods

In this prospective randomised controlled trial (ethics approval no. 5094-14DRKS00007928), patients (> 65 years) undergoing elective on-pump cardiac surgery were randomised to intraoperative HA (CytoSorb) during CPB or standard care without HA. Primary outcome was the difference in mean interleukin (IL)-6 serum concentrations between groups on intensive care unit (ICU) admission. The secondary outcomes included various

SUBMITTER: Hohn A 

PROVIDER: S-EPMC11639119 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature