On the inverse association between the number of QTL and the trait-specific genomic relationship of a candidate to the training set.

ABSTRACT:

Background

Accuracy of genomic prediction depends on the heritability of the trait, the size of the training set, the relationship of the candidates to the training set, and the Min(NQTL,Me) , where NQTL is the number of QTL and Me is the number of independently segregating chromosomal segments. Due to LD, the number Qe of independently segregating QTL (effective QTL) can be lower than Min(NQTL,Me) . In this paper, we show that Qe is inversely associated with the trait-specific genomic relationship of a candidate to the training set. This provides an explanation for the inverse association between Qe and the accuracy of prediction.

Methods

To quantify the genomic relationship of a candidate to all members of the training set, we considered the k2 statistic that has been prev

SUBMITTER: Stricker C 

PROVIDER: S-EPMC11639121 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature