Assessment of combined serum sST2 and AFP levels in the diagnosis of hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a common malignant tumor with high morbidity and mortality. Alpha-fetoprotein (AFP) is the most widely used diagnostic serum biomarker, but it still has limited accuracy in detecting HCC, suggesting the necessity of seeking more ideal biomarkers with high sensitivity and specificity. Soluble growth stimulation gene 2 (sST2) form of growth stimulating expression gene 2 (ST2), is expressed in various organs and can bind competitively to interleukin 33 (IL-33). Whether sST2 can serve as a serum biomarker for HCC is largely unknown.

Objective

To investigate the value of sST2 as a serum diagnostic marker for HCC.

Methods

This study included 93 newly diagnosed HCC patients (HCC group), 90 chronic hepatitis B patients (CHB group),

SUBMITTER: Tang X 

PROVIDER: S-EPMC11639131 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature