The geometry of admixture in population genetics: the blessing of dimensionality.

ABSTRACT: We present a geometry-based interpretation of the f-statistics framework, commonly used in population genetics to estimate phylogenetic relationships from genomic data. The focus is on the determination of the mixing coefficients in population admixture events subject to post-admixture drift. The interpretation takes advantage of the high dimension of the dataset and analyzes the problem as a dimensional reduction issue. We show that it is possible to think of the f-statistics technique as an implicit transformation of the genomic data from a phase space into a subspace where the mapped data structure is more similar to the ancestral admixture configuration. The 2-way mixing coefficient is, as a matter of fact, carried out implicitly in this subspace. In addition, we propose the admixture

SUBMITTER: Oteo JA 

PROVIDER: S-EPMC11639143 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature