Differential Impact of Adolescent or Adult Stress on Behavior and Cortical Parvalbumin Interneurons and Perineuronal Nets in Male and Female Mice.

ABSTRACT:

Background

Stress has become a common public health concern, contributing to the rising prevalence of psychiatric disorders. Understanding the impact of stress considering critical variables, such as age, sex, and individual differences, is of the utmost importance for developing effective intervention strategies.

Methods

Stress effects (daily footshocks for 10 days) during adolescence (postnatal day [PND] 31-40) and adulthood (PND 65-74) were investigated on behavioral outcomes and parvalbumin (PV)-expressing GABAergic interneurons and their associated perineuronal nets (PNNs) in the prefrontal cortex of male and female mice 5 weeks post stress.

Results

In adulthood, adolescent stress induced behavioral alterations in male mice, including anxiety-like behaviors, soci

SUBMITTER: Santos-Silva T 

PROVIDER: S-EPMC11639180 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature