RecGOBD: accurate recognition of gene ontology related brain development protein functions through multi-feature fusion and attention mechanisms.

ABSTRACT:

Motivation

Protein function prediction is crucial in bioinformatics, driven by the growth of protein sequence data from high-throughput technologies. Traditional methods are costly and slow, underscoring the need for computational solutions. While deep learning offers powerful tools, many models lack optimization for brain development datasets, critical for neurodevelopmental disorder research. To address this, we developed RecGOBD (Recognition of Gene Ontology-related Brain Development protein function), a model tailored to predict protein functions essential to brain development.

Result

RecGOBD targets 10 key gene ontology (GO) terms for brain development, embedding protein sequences associated with these terms. Leveraging advanced pre-trained models, it captures both sequ

SUBMITTER: Xia Z 

PROVIDER: S-EPMC11639192 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature