IL-17 signaling protects against <i>Helicobacter pylori-</i>induced gastric cancer.

ABSTRACT: Helicobacter pylori infection is the predominant risk factor for the development of gastric cancer. Risk is enhanced by specific H. pylori virulence factors, diet, and the inflammatory response. Chronic activation of T helper (Th) 1 and Th17 pathways contributes to prolonged inflammation; yet, higher expression of IL-17 receptor (IL-17RA) is a favorable prognostic marker for survival after gastric cancer diagnosis. The protective impact of IL-17RA signaling is not understood. To investigate if IL-17RA signaling protects during H. pylori-induced carcinogenesis, the transgenic InsGAS^tg/tg mouse, which is prone to H. pylori-induced gastric cancer, was utilized. InsGAS^tg/tg mice and InsGAS^tg/tg

SUBMITTER: Brackman LC 

PROVIDER: S-EPMC11639209 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature