Numerical and in vitro experimental studies for assessing the blood hematocrit and oxygenation with the dual-wavelength photoacoustics.

ABSTRACT: Assessing the blood hematocrit (Hct) and oxygenation (SO 2 ) levels are essential for diagnosing numerous blood-related diseases. This study examines the ability of the photoacoustic (PA) technique for quantitative evaluation of these parameters. We conducted the Monte Carlo and k-Wave simulations to compute PA signals at four different optical wavelengths from test blood samples followed by rigorous in vitro experiments. This method can estimate the Hct and SO 2 levels faithfully with ≥ 95% and ≥ 93% accuracies, respectively in the physiologically relevant hematocrits utilizing PA signals generated at 700 and 1000 nm optical wavelengths. A 2% decrease in the scattering anisotropy factor demotes SO 2 estimation by ≈ 27%. This study provides sufficient insight into how the opto-chemical par

SUBMITTER: Paul S 

PROVIDER: S-EPMC11639327 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature