Associations between exposure to air pollution and sex hormones during the menopausal transition.

ABSTRACT: Menopause is a significant milestone in a woman's life, characterized by decreasing estradiol (E2) and increasing follicle-stimulating hormone (FSH) levels. Growing evidence suggests that air pollution may affect reproductive health and disrupt hormone profiles, yet the associations in women undergoing menopausal transition (MT) remains underexplored. We examined the associations between annual air pollutant exposures and repeated measures of E2 and FSH in 1365 women with known final menstrual period (FMP) date from the Study of Women's Health Across the Nation. Air pollution was calculated as the annual averages of 24-h average PM_2.5 levels, daily one-hour maximum NO₂ levels, and daily 8-h maximum O₃ levels. Linear mixed models with piece-wise linear splin

SUBMITTER: Wang X 

PROVIDER: S-EPMC11639416 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature