T1 relaxation and axon fibre configuration in human white matter.

ABSTRACT: Understanding the effects of white matter (WM) axon fibre microstructure on T1 relaxation is important for neuroimaging. Here, we have studied the interrelationship between T1 and axon fibre configurations at 3T and 7T. T1 and S0 (=signal intensity at zero TI) were computed from MP2RAGE images acquired with six inversion recovery times. Multishell diffusion MRI images were analysed for fractional anisotropy (FA); MD; V1; the volume fractions for the first (f₁), second (f₂) and third (f₃) fibre configuration; and fibre density cross-section images for the first (fdc₁), second (fdc₂) and third (fdc₃) fibres. T1 values were plotted as a function of FA, f₁, f₂, f₃, fdc₁, fdc₂

SUBMITTER: Hutchinson G 

PROVIDER: S-EPMC11639506 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature