A Bayesian framework for causal analysis of recurrent events with timing misalignment.

ABSTRACT: Observational studies of recurrent event rates are common in biomedical statistics. Broadly, the goal is to estimate differences in event rates under 2 treatments within a defined target population over a specified follow-up window. Estimation with observational data is challenging because, while membership in the target population is defined in terms of eligibility criteria, treatment is rarely observed exactly at the time of eligibility. Ad hoc solutions to this timing misalignment can induce bias by incorrectly attributing prior event counts and person-time to treatment. Even if eligibility and treatment are aligned, a terminal event process (eg, death) often stops the recurrent event process of interest. In practice, both processes can be censored so that events are not observed over t

SUBMITTER: Oganisian A 

PROVIDER: S-EPMC11639529 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature