Systematic in-silico evaluation of fibrosis effects on re-entrant wave dynamics in atrial tissue.

ABSTRACT: Despite the key role of fibrosis in atrial fibrillation (AF), the effects of different spatial distributions and textures of fibrosis on wave propagation mechanisms in AF are not fully understood. To clarify these aspects, we performed a systematic computational study to assess fibrosis effects on the characteristics and stability of re-entrant waves in electrically-remodelled atrial tissues. A stochastic algorithm, which generated fibrotic distributions with controlled overall amount, average size, and orientation of fibrosis elements, was implemented on a monolayer spheric atrial model. 245 simulations were run at changing fibrosis parameters. The emerging propagation patterns were quantified in terms of rate, regularity, and coupling by frequency-domain analysis of correspondent synthet

SUBMITTER: Mase M 

PROVIDER: S-EPMC11639732 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature