Sex Determines Anterior Cingulate Cortex Cortical Thickness in the Course of Depression.

ABSTRACT:

Background

Major depressive disorder (MDD) is a severe psychiatric disorder affecting women more than men. Changes in anterior cingulate cortex cortical thickness (ACC CT) may be crucial to understanding sex influences in MDD onset and recurrency.

Methods

Taken from the large open-source REST-meta-MDD database, we contrasted 499 patients with MDD (381 first-episode MDD, 118 recurrent MDD) and 524 healthy control participants using linear mixed-effects models and normative modeling and investigated whether sex differences affected ACC CT and its subregions differently during the course of depressive illness.

Results

Overall, females showed thinner ACC CT compared with males. Female patients with a first depressive episode showed significantly thinner ACC CT compared wi

SUBMITTER: Wu GR 

PROVIDER: S-EPMC11639738 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature