MRI-Based Circumferential Strain in Boys with Early Duchenne Muscular Dystrophy Cardiomyopathy.

ABSTRACT: Background: In boys with Duchenne muscular dystrophy (DMD), cardiomyopathy has become the primary cause of death. Although both positive late gadolinium enhancement (LGE) and reduced left ventricular ejection fraction (LVEF) are late findings in a DMD cohort, LV end-systolic circumferential strain at middle wall (E_cc) serves as a biomarker for detecting early impairment in cardiac function associated with DMD. However, E_cc derived from cine Displacement Encoding with Stimulated Echoes (DENSE) has not been quantified in boys with DMD. We aim to: (1) use cine DENSE to quantify regional E_cc in LGE negative (-) boys with DMD and healthy controls; and (2) compare E_cc with LVEF in terms of differentiating DMD boys with LGE (-) from healthy boys.

SUBMITTER: Liu ZQ 

PROVIDER: S-EPMC11639811 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature