First Report of Polymorphisms and Genetic Characteristics of Prion-like Protein Gene (PRND) in Cats.

ABSTRACT: Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal cellular prion protein (PrP^C) into its infectious isoform (PrP^Sc). Although prion diseases in humans, sheep, goats, and cattle have been extensively studied, feline spongiform encephalopathy (FSE) remains poorly understood. Genetic factors, particularly polymorphisms in the prion protein gene (PRNP) and prion-like protein gene (PRND), have been linked to prion disease susceptibility in various species. However, no studies have yet investigated the PRND gene in cats with respect to prion diseases. Therefore, we investigated polymorphisms in the feline PRND gene and analyzed their genetic characteristics. We sequenced the coding region of the

SUBMITTER: Jeong MJ 

PROVIDER: S-EPMC11639842 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature