Evaluation of Serum YKL-40 in Canine Multicentric Lymphoma: Clinical and Diagnostic Implications.

ABSTRACT: YKL-40, a secretory glycoprotein, is known as a prognostic biomarker in human cancers, but its role in canine multicentric lymphoma is not well understood. This study aimed to investigate serum YKL-40 levels in thirty dogs with multicentric lymphoma to determine their prognostic value, association with patient characteristics, and potential to predict chemotherapy response. Serum samples were collected before, during, and after chemotherapy, and YKL-40 level was measured using ELISA. The results showed that the pretreatment serum YKL-40 levels were significantly higher in dogs with multicentric lymphoma (394.0 pg/mL, n = 30) than in healthy controls (218.6 pg/mL, n = 11) (p = 0.012). While a cutoff value of 445.1 pg/mL was observed, further studies are needed to clarif

SUBMITTER: Kuo CC 

PROVIDER: S-EPMC11639910 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature