Integron-Mediated Antimicrobial Resistance and Virulence Factors in <i>Salmonella</i> Typhimurium Isolated from Poultry.

ABSTRACT: This study investigates antimicrobial-resistant (AMR) Salmonella Typhimurium in poultry, focusing on how class I integrons contribute to AMR and virulence. Using whole genome sequencing, researchers analyzed 26 S. Typhimurium isolates from U.S. poultry, finding that three isolates contained integrons (1000 base pairs each). These integron-positive isolates exhibited significantly higher resistance to beta-lactams, phenicols, and tetracyclines compared to integron-free isolates (p = 0.004, 0.009, and 0.02, respectively) and harbored genes like ges, imp, and oxa, which are linked to extended-spectrum beta-lactamase resistance. Most AMR gene classes (64%) were chromosome-based, with integron-positive isolates showing a broader array of resistance gene

SUBMITTER: Kim E 

PROVIDER: S-EPMC11640015 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature