Simulated Galactic Cosmic Radiation Exposure-Induced Mammary Tumorigenesis in <i>Apc</i>^Min/+ Mice Coincides with Activation of ERα-ERRα-SPP1 Signaling Axis.

ABSTRACT:

Background

Exposure to galactic cosmic radiation (GCR) is a breast cancer risk factor for female astronauts on deep-space missions. However, the specific signaling mechanisms driving GCR-induced breast cancer have not yet been determined.

Methods

This study aimed to investigate the role of the estrogen-induced ERα-ERRα-SPP1 signaling axis in relation to mammary tumorigenesis in female Apc^Min/+ mice exposed to simulated GCR (GCRsim) at 100-110 days post-exposure.

Results

In GCRsim-exposed mice, we observed marked elevations in serum estradiol, increased ductal overgrowth, ERα activation, and upregulation of ERα target genes with pro-tumorigenic functions in mammary tissues that was coupled with a higher mammary tumorigenesis, relative to control. Addi

SUBMITTER: Kumar K 

PROVIDER: S-EPMC11640058 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature