Could <i>SLC26A7</i> Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?

ABSTRACT:

Background/objectives

A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).

SUBMITTER: Titov SE 

PROVIDER: S-EPMC11640196 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature