Analysis of the Sensitivity and Specificity of Histopathological Findings for Diagnosing Lupus Nephritis.

ABSTRACT:

Background

Since the introduction of the SLICC criteria in 2012, biopsy-proven lupus nephritis (LN) has been the only independent diagnostic criterion for systemic lupus erythematosus (SLE). This was reaffirmed by the EULAR/ACR in 2019, emphasizing the importance of renal biopsy in LN. However, the current classification lacks specific histopathological criteria for defining LN. This study describes the histological findings of patients with LN, compares them with those of other glomerular diseases, and evaluates their diagnostic accuracy in a large Latin American population.

Methods

This retrospective cohort included 731 kidney biopsies from two distinct academic centers. The patients were divided into two groups as follows: a LN group and a control group comprising patient

SUBMITTER: da Luz Neto ER 

PROVIDER: S-EPMC11640231 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature