Impact of <i>Nannochloropsis oceanica</i> and <i>Chlorococcum amblystomatis</i> Extracts on UVA-Irradiated on 3D Cultured Melanoma Cells: A Proteomic Insight.

ABSTRACT: Melanoma is one of the most malignant forms of skin cancer, characterised by the highest mortality rate among affected patients. This study aims to analyse and compare the effects of lipid extracts from the microalgae Nannochloropsis oceanica (N.o.) and Chlorococcum amblystomatis (C.a.) on the intra and extracellular proteome of UVA-irradiated melanoma cells using a three-dimensional model. Proteomic analysis revealed that UVA radiation significantly increases the levels of pro-inflammatory proteins in melanoma cells. Treatment with algae extracts reduced these protein levels in both non-irradiated and irradiated cells. Furthermore, untreated cells released proteins responsible for cell growth and proliferation into the medium, a process hindered by UVA radiatio

SUBMITTER: Gegotek A 

PROVIDER: S-EPMC11640244 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature