The Molecular Mechanism of Farnesoid X Receptor Alleviating Glucose Intolerance in Turbot (<i>Scophthalmus maximus</i>).

ABSTRACT: To explore the molecular targets for regulating glucose metabolism in carnivorous fish, the turbot (Scophthalmus maximus) was selected as the research object to study. Farnesoid X receptor (FXR; NR1H4), as a ligand-activated transcription factor, plays an important role in glucose metabolism in mammals. However, the mechanisms controlling glucose metabolism mediated by FXR in fish are not understood. It was first found that the protein levels of FXR and its target gene, small heterodimer partner (SHP), were significantly decreased in the high-glucose group (50 mM, HG) compared with those in the normal glucose group (15 mM, CON) in primary hepatocytes of turbot. By further exploring the function of FXR in turbot, the full length of FXR in turbot was cloned, and its nuclear localizati

SUBMITTER: Qin G 

PROVIDER: S-EPMC11640315 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature