Preclinical Photodynamic Therapy Targeting Blood Vessels with AGuIX^® Theranostic Nanoparticles.

ABSTRACT: Background: Glioblastoma multiforme (GBM) is the most common highly aggressive, primary malignant brain tumor in adults. Current experimental strategies include photodynamic therapy (PDT) and new drug delivery technologies such as nanoparticles, which could play a key role in the treatment, diagnosis, and imaging of brain tumors. Objectives: The purpose of this study was to test the efficacy of PDT using AGuIX-TPP, a polysiloxane-based nanoparticle (AGuIX) that contains TPP (5,10,15,20-tetraphenyl-21H,23H-porphine), in biological models of glioblastoma multiforme and to investigate the vascular mechanisms of action at multiple complexity levels. Methods: PDT effects were studied in monolayer and spheroid cell culture, as well as tumors in chicken chorioallantoic membra

SUBMITTER: Kowolik E 

PROVIDER: S-EPMC11640380 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature