Immunohistochemical Staining Properties of Osteopontin and Ki-67 in Feline Meningiomas.

ABSTRACT: The high recurrence rate of feline meningioma despite the generally benign histomorphology warrants additional markers of clinical aggressiveness. The Ki-67 index is commonly used as prognostic marker for meningioma recurrence in people. Osteopontin (OPN) is a protein involved in tumor progression and may be a potential malignancy marker. To date, osteopontin expression has not been investigated in feline meningioma. The aim of this study was to evaluate the extent of Ki-67 and osteopontin immunostaining of feline meningioma and to find possible associations with WHO (World Health Organization) grades and subtypes. Fifty-three feline meningioma samples were graded according to the human WHO classification and underwent immunohistochemical examination for Ki-67 and OPN. Fifty samples were c

SUBMITTER: Gradner G 

PROVIDER: S-EPMC11640386 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature