The Anti-Inflammatory Properties of Polysaccharides Extracted from <i>Moringa oleifera</i> Leaves on IEC6 Cells Stimulated with Lipopolysaccharide In Vitro.

ABSTRACT: Moringa oleifera (M. oleifera) is a plant with significant medicinal and nutritional value and contains various bioactive compounds, particularly in its leaves (MOL). This study sought to explore the impact of M. oleifera leaf polysaccharides (MOLPs) on lipopolysaccharide (LPS)-activated intestinal epithelial cells (IEC6) and to uncover the mechanisms involved. The cytotoxicity of MOLP on IEC6 cells was assessed using the Cell Counting Kit-8 (CCK-8) assay, which demonstrated a safe concentration range of 0-1280 µg/mL. The impact of MOLP on cell viability was further evaluated over 12 to 48 h. IEC6 cells were treated with three concentrations of MOLP low (25 µg/mL), medium (50 µg/mL), and high (100 µg/mL) alongside LPS (50 µg/mL) stimulation for one day. The findings re

SUBMITTER: Husien HM 

PROVIDER: S-EPMC11640475 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature