Extract of <i>Curculigo capitulata</i> Ameliorates Postmenopausal Osteoporosis by Promoting Osteoblast Proliferation and Differentiation.

ABSTRACT: Postmenopausal osteoporosis (PMOP) is a bone disease characterized by bone thinning and an increased risk of fractures due to estrogen deficiency. Current PMOP therapies often result in adverse side effects. The traditional medicinal plant Curculigo capitulata is commonly used to strengthen bones and support kidney function, but its role in treating PMOP is not well understood. This study aims to investigate the therapeutic effects of the total extract of Curculigo capitulata (Eocc) on PMOP and to explore the underlying mechanisms. The major components of the extract were identified using HPLC. Transcriptomics was employed to predict potential targets. An osteogenic differentiation model of MC3T3-E1 cells was used in vitro. The osteogenic potential of the Eocc was assessed th

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11640542 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature