Imaging of prostate micro-architecture using three-dimensional wide-field optical coherence tomography.

ABSTRACT: Prostate cancer is a global health issue that requires new diagnostic methods to provide accurate and precise visualization of prostate tissue on the micro-scale. Such methods have the potential to improve nerve-sparing surgery and to provide image guidance during prostate biopsy. In this feasibility study, we assess the potential of en face three-dimensional wide-field optical coherence tomography (OCT), covering a volumetric imaging field-of-view up to 46 × 46 × 1 mm³, to visualize micro-architecture in 18 freshly excised human prostate specimens. In each case, validation of contrast in OCT images is provided by co-registered wide-field histology images. Using this co-registration, we demonstrate that OCT can distinguish between healthy and cancerous glands at different

SUBMITTER: Skrok MK 

PROVIDER: S-EPMC11640564 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature