Strategies to Improve Hydrolysis Efficiency of Fish Skin Collagen: Study on ACE Inhibitory Activity and Fibroblast Proliferation Activity.

ABSTRACT: Collagen peptides play a crucial role in promoting skin elasticity and enhancing joint health, with potential functions to be explored. Enzyme hydrolysis is crucial for the molecular weight and sequence of peptides, influencing the bio-activity. In this study, the angiotensin-converting enzyme (ACE) inhibitory activity and fibroblast proliferation activity of differentially molecular weight peptides derived from dual- or triple-enzyme hydrolysis were compared. Ultrafiltration membrane filtration was used to separate the hydrolyzed prepared collagen peptides into two components based on the molecular size. The results showed that the low-molecular-weight peptide fraction containing peptides with P at the C-terminal, such as KP, RP, and POGP, exhibited high ACE inhibitory activity. The low-m

SUBMITTER: Chang C 

PROVIDER: S-EPMC11640598 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature