Genetic Downregulation of GABA_B Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord.

ABSTRACT: GABAergic signaling and GABA_B receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying how spinal oligodendrocyte precursor cells (OPCs) respond to injuries and neurodegenerative diseases like multiple sclerosis. Taking advantage of the temporally controlled and cell-specific genetic downregulation of GABA_B receptors from OPCs, our investigation addresses their specific influence on OPC behavior in the gray and white matter of the mouse spinal cord. Our results show that, while GABA_B receptors do not significantly alter spinal cord myelination under physiological conditions, they distinctly regulate the OPC d

SUBMITTER: Gobbo D 

PROVIDER: S-EPMC11640606 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature