Metabolic and Regulatory Pathways Involved in the Anticancer Activity of Perillyl Alcohol: A Scoping Review of In Vitro Studies.

ABSTRACT:

Background/objectives

Perillyl alcohol (POH), a plant-derived compound, has demonstrated anti-tumor activity across various human cancers. Understanding the regulatory pathways through which POH exerts its effects is crucial for identifying new therapeutic opportunities and exploring potential drug repositioning strategies. Therefore, this scoping review aims to provide a comprehensive overview of the metabolic and regulatory pathways involved in the anticancer effects of POH, based on in vitro evidence.

Methods

Following the PRISMA-ScR 2018 guidelines, a systematic search was conducted in the PUBMED, Web of Science, and Scopus databases.

Results

A total of 39 studies were included, revealing that POH exerts its biological effects by modulating several pathways, inclu

SUBMITTER: Batista Brochado AC 

PROVIDER: S-EPMC11640718 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature