Chronological Dynamics of Neuroinflammatory Responses in a High-Fat Diet Mouse Model.

ABSTRACT: Obesity is known to affect various tissues and contribute to conditions such as neuroinflammation. However, the specific mechanisms and time-dependent progression of these effects across different tissues remain unclear. In this study, we monitored gene expression at intervals to examine the effects of a high-fat diet (HFD) on brain, liver, adipose, and muscle tissues in male C57/BJ mice, with a particular focus on neuroinflammation. Early inflammatory responses exhibit a progression that starts in the liver, extends to adipose tissue, and subsequently involves muscle and brain tissues. Although the brain did not show significant gene expression of inflammatory responses, mechanisms leading to neuroinflammation increased after 24 weeks, possibly through systemic chronic inflammation (SCI).

SUBMITTER: Bae HR 

PROVIDER: S-EPMC11640818 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature