In Vivo and In Vitro Studies Assessing the Safety of Monosodium Glutamate.

ABSTRACT: The controversial results of research on monosodium glutamate demand a new data corpus for the overall safety evaluation. Both animal and cellular model systems have been used to add a multilevel scope on its biological effects. The Drosophila melanogaster animal model has been used to test a wide range of concentrations for safety purposes: toxicity, genotoxicity, longevity and health span. Medium concentrations corresponding to the human acceptable daily intake (ADI) (0.06 mg/mL) were not toxic nor genotoxic for Drosophila and safe for the lifespan parameters. Once safety was determined, the possible nutraceutical effects of monosodium glutamate was monitored in terms of antitoxicity, antigenotoxicity assays and health span. The results for protective activity against hydro

SUBMITTER: Merinas-Amo T 

PROVIDER: S-EPMC11640987 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature