The Transcription Factor StuA Regulates Oxidative Stress-Responsive Genes in <i>Trichophyton rubrum</i>.

ABSTRACT: Fungi can remarkably sense and adapt to various extracellular stimuli and stress conditions. Oxidative stress, which results from an imbalance between reactive oxygen species production and antioxidant defenses, leads to cellular damage and death. In Trichophyton rubrum, oxidative stress is managed by a complex antioxidant system, including thioredoxins, glutathione, catalases, peroxidases, and superoxide dismutase, with glutathione playing a crucial role. The fungus also responds to oxidative stress through critical pathways such as the glycerol high-osmolarity pathway, activator protein 1 transcription factor, and responsive regulator SKN7. To better understand the role of the transcription factor StuA in regulating oxidative stress-related genes within these pathways, we conducte

SUBMITTER: Fazolin Petrucelli M 

PROVIDER: S-EPMC11641030 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature