Hypoxic Human Microglia Promote Angiogenesis Through Extracellular Vesicle Release.

ABSTRACT: Microglia, the brain-resident immune cells, orchestrate neuroinflammatory responses and are crucial in the progression of neurological diseases, including ischemic stroke (IS), which accounts for approximately 85% of all strokes worldwide. Initially deemed detrimental, microglial activation has been shown to perform protective functions in the ischemic brain. Besides their effects on neurons, microglia play a role in promoting post-ischemic angiogenesis, a pivotal step for restoring oxygen and nutrient supply. However, the molecular mechanisms underlying microglia-endothelial cell interactions remain largely unresolved, particularly in humans. Using both in vitro and in vivo models, we investigated the angiogenic signature and properties of extracellular vesicles (EVs) released by human mi

SUBMITTER: Testa AM 

PROVIDER: S-EPMC11641038 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature