Nidogen 2 Overexpression Promotes Hepatosteatosis and Atherosclerosis.

ABSTRACT: Clinical and genetic studies strongly support a significant connection between nonalcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular disease (ASCVD) and identify ASCVD as the primary cause of death in NAFLD patients. Understanding the molecular factors and mechanisms regulating these diseases is critical for developing novel therapies that target them simultaneously. Our preliminary immunoblotting experiments demonstrated elevated expression of nidogen 2 (NID2), a basement membrane glycoprotein, in human atherosclerotic vascular tissues and murine steatotic livers. Therefore, we investigated the role of NID2 in regulating hepatosteatosis and atherosclerosis utilizing Western diet-fed Apoe^-/- mice with/without NID2 overexpression. Quantitative

SUBMITTER: Kathuria I 

PROVIDER: S-EPMC11641205 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature