Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea.

ABSTRACT: We determined the relative expression levels of the receptors TrkA, TrkB, TrkC, and p75^NTR and ligands BDNF, NT-3, NGF, and NT-4 with RNAseq analysis on fetal human inner ear samples, located TrkB and TrkC proteins, and quantified BDNF with in situ hybridization on histological sections between gestational weeks (GW) 9 to 19. Spiral ganglion neurons (SGNs) and satellite glia appear to be the main source of BDNF and synthesis peaks twice at GW10 and GW15-GW17. Tonotopical gradients of BDNF revert between GW8 and GW15 and follow a maturation and innervation density gradient in SGNs. NT-3/TrkC follows the same time course of expression as BDNF/TrkB. Immunostaining reveals that TrkB signaling

SUBMITTER: Steinacher C 

PROVIDER: S-EPMC11641258 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature