Gliotic Response and Reprogramming Potential of Human Muller Cell Line MIO-M1 Exposed to High Glucose and Glucose Fluctuations.

ABSTRACT: Retinal neurodegeneration (RN), an early marker of diabetic retinopathy (DR), is closely associated with Müller glia cells (MGs) in diabetic subjects. MGs play a pivotal role in maintaining retinal homeostasis, integrity, and metabolic support and respond to diabetic stress. In lower vertebrates, MGs have a strong regenerative response and can completely repair the retina after injuries. However, this ability diminishes as organisms become more complex. The aim of this study was to investigate the gliotic response and reprogramming potential of the human Müller cell line MIO-M1 cultured in normoglycemic (5 mM glucose, NG) and hyperglycemic (25 mM glucose, HG) conditions and then exposed to sustained high-glucose and glucose fluctuation (GF) treatments to mimic the human diabetic conditions

SUBMITTER: Russo B 

PROVIDER: S-EPMC11641291 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature