Reduction of Alcohol-Dependent Lung Pathological Features in Rats Treated with Fenofibrate.

ABSTRACT: Alcohol use disorder (AUD) is a public health problem characterized by a marked increment in systemic inflammation. In the last few years, it has been described as the role of alcohol in neuroinflammation affecting some aspects of neuronal function. Interestingly, inflammation is reduced with fenofibrate treatment, a PPARα agonist used to treat dyslipidemia. On the other hand, alcohol has been associated with chronic inflammation and fibrosis in the lungs, affecting their normal function and increasing respiratory infections. However, a deep characterization of the role of alcohol in the worsening of chronic respiratory diseases has not been described completely. In this work, we present a novel study using rats treated with alcohol and fenofibrate to evaluate the relevant features of chro

SUBMITTER: Rojas DA 

PROVIDER: S-EPMC11641378 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature