Chemogenetic Modulation of Preoptic <i>Gabre</i> Neurons Decreases Body Temperature and Heart Rate.

ABSTRACT: The preoptic area of the hypothalamus is critical for regulation of brain-body interaction, including circuits that control vital signs such as body temperature and heart rate. The preoptic area contains approximately 70 molecularly distinct cell types. The Gabre gene is expressed in a subset of preoptic area cell types. It encodes the GABA receptor ε-subunit, which is thought to confer resistance to anesthetics at the molecular level, but the function of Gabre cells in the brain remains largely unknown. We generated and have extensively characterized a Gabre-cre knock-in mouse line and used chemogenetic tools to interrogate the function of Gabre cells in the preoptic area. Comparison with macaque GABRE expression revealed the conserved character of Ga

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11641399 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature