Roles of 4'-<i>O</i>-Methylalpinum Isoflavone on Activation of Microglia Induced by Oxysterols.

ABSTRACT: Microglia play a crucial role as immune cells responsible for the brain's defense mechanisms. Similar to the actions of macrophages in the body, microglial cells elicit an inflammatory immune response in the brain. Recent papers highlight activated microglial cells as pivotal contributors to inflammatory responses in the brain, leading to damage to nerve tissue and the onset of Alzheimer's disease (AD). In the brains of AD patients, elevated levels of inflammatory cytokines such as interleukin-6 (IL-6) and oxidized cholesterol metabolites (oxysterols) are observed. These factors are closely associated with inflammatory diseases in the brain. 4'-O-Methylalpinum isoflavone (mAI), derived from Cudrania tricuspidata fruit, possesses antioxidant, neuroprotective, and anti-inflamma

SUBMITTER: Son Y 

PROVIDER: S-EPMC11641445 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature