Effects of Polyvinyl Chloride (PVC) Microplastic Particles on Gut Microbiota Composition and Health Status in Rabbit Livestock.

ABSTRACT: The widespread use of polyvinyl chloride (PVC) and its entry into humans and livestock is of serious concern. In our study, we investigated the impact of PVC treatments on physiological, pathological, hormonal, and microbiota changes in female rabbits. Trend-like alterations in weight were observed in the spleen, liver, and kidney in both low (P1) and high dose (P2) PVC treatment groups. Histopathological examination revealed exfoliation of the intestinal mucosa in the treated groups compared to the control, and microplastic particles were penetrated and embedded in the spleen. Furthermore, both P1 and P2 showed increased 17-beta-estradiol (E2) hormone levels, indicating early sexual maturation. Moreover, the elevated tumor necrosis factor alpha (TNF-α) levels suggest inflammatory reaction

SUBMITTER: Papp PP 

PROVIDER: S-EPMC11641588 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature