Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review.

ABSTRACT: Otitis media (OM) is a frequent disease with incidence rate of 5300 cases per 100,000 people. Recent studies showed that polymicrobial biofilm formation represents a significant pathogenic mechanism in recurrent and chronic forms of OM. Biofilm enables bacteria to resist antibiotics that would typically be recommended in guidelines, contributing to the ineffectiveness of current antimicrobial strategies. Given the challenges of successfully treating bacterial biofilms, there is an growing interest in identifying novel and effective compounds to overcome antibacterial resistance. The objective of this review was to provide an overview of the novel compounds with antibiofilm effects on bacterial biofilm formed by clinical isolates of OM. The systematic review included studies that evaluated

SUBMITTER: Jotic A 

PROVIDER: S-EPMC11641745 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature