Elucidating Sex-Specific Immune Profiles in a Breast Cancer Model.

ABSTRACT: Breast cancer is commonly thought of as a "women's disease". However, men are increasingly diagnosed with the disease, and their mortality rates are disparately higher than those of female patients. The abundance and composition of the immune microenvironment are determinants of breast cancer progression and survival. It is well documented that there are sex-specific differences in the immune response to several diseases, including various cancers. However, the effects of these differences in the context of breast cancer remain to be explored. This study demonstrates sex differences in the hormonal and immune landscape of the MMTV-PyMT transgenic murine model of female and male ER+ breast cancer using single-cell RNA sequencing (scRNA-Seq), whole-slide immunohistochemistry, and flow cytome

SUBMITTER: Hargrove-Wiley E 

PROVIDER: S-EPMC11641823 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature