Activation of Bradykinin B₂ Receptors in Astrocytes Stimulates the Release of Leukemia Inhibitory Factor for Autocrine and Paracrine Signaling.

ABSTRACT: Communications between different cell types within a tissue are often critical for the proper functioning of an organ. In the central nervous system, interactions among neurons and glial cells are known to modulate neurotransmission, energy metabolism, extracellular ion homeostasis, and neuroprotection. Here we showed that bradykinin, a proinflammatory neuropeptide, can be detected by astrocytes, resulting in the secretion of cytokines that act on neurons. In astrocytic cell lines and primary astrocytes, bradykinin and several other ligands acting on G_q-coupled receptors stimulated Ca²⁺ mobilization, which subsequently led to the release of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6). The bradykinin B₂ receptor antagonist, HOE-140, effectively

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11642044 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature