Feline Diabetes Is Associated with Deficits in Markers of Insulin Signaling in Peripheral Tissues.

ABSTRACT: Like humans, cats have a strong relationship between decreasing insulin sensitivity and the development of diabetes with obesity. However, the underlying molecular mechanisms of impaired insulin secretion and signaling in cats remain largely unknown. A total of 54 client-owned nondiabetic lean (n = 15), overweight (n = 15), and diabetic (n = 24) cats were included in the study. The pancreas, liver, and skeletal muscle were quantified for mRNA and protein abundances of insulin and incretin signaling markers. Diabetic cats showed increased liver and muscle adiposity. The pancreas of diabetic cats had decreased transcript abundances of insulin, insulin receptor, insulin-receptor substrate (IRS)-1, glucose transporters (GLUT), and protein abundance of mitogen-activated pro

SUBMITTER: Patra S 

PROVIDER: S-EPMC11642086 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature