Non-<i>Helicobacter pylori Helicobacters</i>, a Treatable Provocateur of Parkinson's Disease: Hypothesis, Evidence and Species Specificity.

ABSTRACT: Epidemiological and eradication trial evidence indicates that Helicobacter pylori, a major causative factor in peptic ulcer and gastric cancer, is a driver of the hypokinesia of Parkinson's disease (PD). Psychological (cognitive impairment, depression and anxiety) and gastrointestinal (peptic ulceration and constipation) PD features can precede the symptomatic onset of motor features by decades. We hypothesise that the non-H. pylori Helicobacters (NHPH), which have farm, companion and wild animals as their main hosts, can have a role in PD aetiopathogenesis. In those occupationally at risk of NHPH infection, we address whether there is increased mortality with PD, or depression or suicide. Our systematic review gave evidence that occupational exposure to animals/their product

SUBMITTER: Wang W 

PROVIDER: S-EPMC11642523 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature