Graph analysis of guilt processing network highlights links with subclinical anxiety and self-blame.

ABSTRACT: Maladaptive forms of guilt, such as excessive self-blame, are common characteristics of anxiety and depressive disorders. The underlying network consists of multiple associative areas, including the superior anterior temporal lobe (sATL), underlying the conceptual representations of social meaning, and fronto-subcortical areas involved in the affective dimension of guilt. Nevertheless, despite understanding the circuitry's anatomy, network-level changes related to subclinical anxiety and self-blaming behaviour have not been depicted. To fill this gap, we used graph theory analyses on a resting-state functional and diffusion-weighted magnetic resonance imaging dataset of 78 healthy adults (20 females, 20-35 years old). Within the guilt network, we found increased functional contributions of

SUBMITTER: Zareba MR 

PROVIDER: S-EPMC11642621 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature